- Glutamic acid is also referred to as glutamate. The finding of glutamate receptors throughout the gastrointestinal tract has opened up a new vista in glutamate function. The human body is able to produce L-glutamine itself, from L-glutamic acid through the glutamate ammonium ligase. It is non-essential amino acid in humans which refers body could synthesize it. - … Glutamate cannot cross the blood-brain barrier, so even if it is obtained through the diet, it also has to be synthesized in the brain.It is synthesized from α-ketoglutarate, which is an intermediate molecule generated during the Krebs Cycle.. Glutamic Acid vs. Glutamate. While neither is regarded as essential, each plays important metabolic roles during exercise demand. It is an anion of the glutamic acid and upon its synthesis, glutamine acts as a precursor. Glutamate is a type of amino acid that is considered as the most abundant stimulating neurotransmitter present in the nervous system. - Glutamic acid is a non-essential amino acid. Furthermore, the glutamate serves as an excitatory neurotransmitter in the brain while the glutamic acid serves as an amino acid precursor in proteins. Glutamic acid can be found in animal and plant proteins. When glutamic acid loses a hydrogen ion from its carboxyl group, it forms glutamate. Glutamic acid is a nonessential amino acid, which is mainly used and produced in the form of its sodium salt as monosodium glutamate (MSG). Glutamic acid (or Glutamate) is a major mediator of excitatory signals in the brain and is involved in most aspects of normal brain function including cognition, memory and learning. Glutamate interaction with specific taste cells in the tongue is a major component of umami taste. Glutamic acid is generally safe for children between the ages of 3-18 years old who take it by mouth. Glutamic acid HCL powder is another popular glutamate supplement.It contains hydrochloric acid (HCL) to help it dissolve in liquids and to ease digestion. Glutamic Acid, or its ionic form, Glutamate, and Glutamine are under-rated "good" dietary amino acids found in most high protein foods. Side Effects. The main difference between glutamate and glutamic acid is that the glutamate is the anionic form of glutamic acid, which is one of the twenty essential amino acids that occur in both animals and plants. The amino acids glutamine and glutamic acid are closely related in a chemical sense. It is an excitatory neurotransmitter in vertebrate nervous system. Glutamate is truly a functional amino acid. Glutamic acid is a α-amino acid, with symbol Glu or E, is used by all living beings in protein biosynthesis.